The above suggested air changes per hour are only a design rule of thumb.
Clean room design layout.
A cascading air flow design and positive pressure hvac calibration move the cleanest air at the highest pressure iso 7.
Supplying airflow in sufficient volume and cleanliness to support the cleanliness rating of the room.
High pressure air in clean areas prevents dirty air from leaking into the cleanroom from adjacent.
Introducing air in a manner to prevent stagnant areas where particles could accumulate.
A clean room gmp cleanroom in my mind are a combination of engineering design fabrication finish and operational controls control strategy that are required to convert a normal room to a clean room.
Read it in detail here.
The above suggested air changes per hour are only a design rule of thumb.
Clean room design in sterile pharmaceutical manufacturing has an important role in minimizing the contamination.
Basic clean room requirements designs for gmp clean rooms what is a clean room.
The 4 important air conditioning design considerations for clean room system design are.